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The principal cytochrome P450 isoenzyme concerned seems for being CYP2E1, with CYP1A2 and CYP3A4 as additional pathways. Somewhere around 85% of an oral dose seems during the urine inside 24 hrs of administration, most as being the glucuronide conjugate, with smaller quantities of other conjugates and unchanged drug [see OVERDOSAGE] for toxicity de